Read e-book online Anticancer Agents from Natural Products, Second Edition PDF

By Gordon M. Cragg,David G. I. Kingston,David J. Newman

ISBN-10: 1439813825

ISBN-13: 9781439813829

The method of drug discovery from ordinary resources has yielded many very important new prescribed drugs inaccessible through different routes. in lots of instances the remoted traditional product will not be an efficient drug for any of numerous purposes, however it however may possibly develop into a drug via chemical amendment or have a singular pharmacophore for destiny drug layout. In summarizing the prestige of normal items as melanoma chemotherapeutics, Anticancer brokers from normal items, moment Edition covers the:

  • History of every coated drug—a dialogue of its mechanism on motion, medicinal chemistry, synthesis, and scientific applications

  • Potential for novel drug discovery by using genome mining in addition to destiny advancements in anticancer drug discovery

  • Important biosynthetic techniques to "unnatural" usual items

Anticancer brokers from typical items, moment Edition discusses how complicated target-oriented synthesis—enabled through ancient advances in methodology—has drastically increased the scope of the potential. This publication covers the present clinically used anticancer brokers which are both typical items or are in actual fact derived from usual product leads. It additionally experiences drug applicants at present in scientific improvement considering a lot of those may be clinically used medications sooner or later.

Examples contain the medicine etoposide and teniposide derived from the lead compound podophyllotoxin; various analogs derived from taxol; topotecan, derived from camptothecin; and the substitute scientific applicants, E7389 and HTI-286, constructed from the marine leads, halichondrin B and hemiasterlin.

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Anticancer Agents from Natural Products, Second Edition by Gordon M. Cragg,David G. I. Kingston,David J. Newman

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